Rational design of supramolecular hemin/G-quadruplex–dopamine aptamer nucleoapzyme systems with superior catalytic performance
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چکیده
منابع مشابه
Rational design of supramolecular hemin/G-quadruplex–dopamine aptamer nucleoapzyme systems with superior catalytic performance
The rational design of a set of hemin/G-quadruplex (hGQ)–dopamine binding aptamer (DBA) conjugates, acting as nucleoapzymes, is described. The nucleoapzyme constructs consist of a hGQ DNAzyme as a catalytic unit and DBA as a substrate binding unit that are brought into spatial proximity by a duplex scaffold composed of complementary oligonucleotide strands. When the hGQ unit is linked to the du...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2016
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c5sc04832j